EUDRAGIT® FS 30 D - A Versatile Polymer for Controlled Release Applications
EUDRAGIT® FS 30 D is the aqueous dispersion of an anionic copolymer based on methyl acrylate, methyl methacrylate and methacrylic acid. It is insoluble in acidic media, but dissolves by salt formation above pH 7.0. Apart from its enteric properties, its dissolution at a higher pH value allows targeted colon delivery.
With a glass transition temperature of 48 °C, EUDRAGIT® FS 30 D is a very flexible polymer. Due to the low minimum film forming temperature only small amounts of plasticzer are required to get a smooth film formation.
Summary of product advantages
- A solubility above pH 7.0 allows specific colon targeting
- Because of its flexibility it is particularly suitable for multi unit dosage forms
- Matrix systems with EUDRAGIT® FS 30 D will release 100% of the drug
- Polymer amounts of 10 to 20% are sufficient to get a pH-independent matrix
- The flexibility of EUDRAGIT® FS 30 D makes this polymer particularly suitable for the mixing with EUDRAGIT® L 30 D-55.
- Amounts below 50% do only influence the flexibility of the EUDRAGIT® L 30 D-55 coating, not the release profile. With amounts > 75% specific sites in the GI tract can be targeted